CPOWeeds is a version of Danish Crop Protection online adjusted to conditions in North-eastern Spain. The predicted efficacies and the yield obtained with CPOWeeds were validated in winter cereal field trials from 2010 to 2013. The predictions from CPOWeeds were compared to the actually achieved efficacies in the field trials for the nine weed species at different developmental stages and for 84.2% of the comparisons the obtained efficacies were equal to or higher than predicted. It was concluded that the use of CPOWeeds allowed optimisation of the herbicide application with a very high robustness. The recommendations were satisfactorily for the conditions of the Northeast of Spain and have the potential to decrease the amount of applied herbicides by at least 30%. Therefore, it can be an important tool in Integrated Weed Management.